hormone-induced variation of phosphatidate phosphohydrolase activity in various tissues of pregnant rats

نویسندگان

بهرام حقیقی

bahram haghighi محبوبه فرسادی

mahboobeh farsadi

چکیده

variations in phosphatidate phosphohydrolase (pap) activity and triacylglycerol concentration were measured in pregnant and hormone-treated non-pregnant female rats. pap activity in adipose tissue was elevated by 61% during pregnancy. the increase in the enzyme activity was paralleled with a rise in serum triacylglycerol concentration (44%). estradiol injecting into non-pregnant rats increased pap activity of both adipose tissue (19.8%) and the liver (26%). progesterone also elevated the enzyme activities of adipose tissue and liver by 10% and 55%, respectively. both hormones increased serum triacylglycerol concentration (20-29%). the data demonstrated that hypertriglyceridemia observed during pregnancy was mediated through the hormonal effects on pap activity, a key enzyme in glycerolipid metabolism.

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Hormone-Induced Variation of Phosphatidate Phosphohydrolase Activity in Various Tissues of Pregnant Rats

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عنوان ژورنال:
iranian biomedical journal

جلد ۵، شماره ۲، صفحات ۱۰۳-۱۰۶

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